1Washington Univ. in St. Louis (United States) 2Washington Univ. School of Medicine in St. Louis (United States) 3ICFO - Institut de Ciències Fotòniques (Spain) 4Institució Catalana de Recerca i Estudis Avançats (Spain)
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High-density speckle contrast optical tomography (HD-SCOT) is a potentially attractive technique for bedside imaging of cerebral blood flow (CBF). To evaluate the performance of HD-SCOT, we built a pipeline with an anatomical head model for simulating measurements and reconstructed images. We observed that the cortical region is well represented by measurements with source-detector distance at least 29 mm. Including larger source-detector distances can reduce localization errors but with reduced signal-to-noise ratio (SNR). Imaging performance is highly dependent on the exposure time, with optimal exposure time dependent on the noise model. Future HD-SCOT systems will be designed using these results.
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Chen-Hao P. Lin, Inema E. Orukari, Lisa Kobayashi Frisk, Manish Verma, Sumana Chetia, Adam T. Eggebrecht, Turgut Durduran, Joseph P. Culver, Jason W. Trobaugh, "Investigation of speckle contrast optical tomography performance for imaging cerebral blood flow in a human head," Proc. SPIE PC11945, Clinical and Translational Neurophotonics 2022, PC1194502 (7 March 2022); https://doi.org/10.1117/12.2610101