Numerical simulation and analysis of accurate blood oxygenation measurement by using optical resolution photoacoustic microscopy

Tianhao Yu; Qian Li; Lin Li; Chuanqing Zhou

doi:10.1117/12.2245681

31 October 2016 Numerical simulation and analysis of accurate blood oxygenation measurement by using optical resolution photoacoustic microscopy

Tianhao Yu, Qian Li, Lin Li, Chuanqing Zhou

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Proceedings Volume 10024, Optics in Health Care and Biomedical Optics VII; 100242C (2016) https://doi.org/10.1117/12.2245681
Event: SPIE/COS Photonics Asia, 2016, Beijing, China

Abstract

Accuracy of photoacoustic signal is the crux on measurement of oxygen saturation in functional photoacoustic imaging, which is influenced by factors such as defocus of laser beam, curve shape of large vessels and nonlinear saturation effect of optical absorption in biological tissues. We apply Monte Carlo model to simulate energy deposition in tissues and obtain photoacoustic signals reaching a simulated focused surface detector to investigate corresponding influence of these factors. We also apply compensation on photoacoustic imaging of in vivo cat cerebral cortex blood vessels, in which signals from different lateral positions of vessels are corrected based on simulation results. And this process on photoacoustic images can improve the smoothness and accuracy of oxygen saturation results.

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Tianhao Yu, Qian Li, Lin Li, and Chuanqing Zhou "Numerical simulation and analysis of accurate blood oxygenation measurement by using optical resolution photoacoustic microscopy", Proc. SPIE 10024, Optics in Health Care and Biomedical Optics VII, 100242C (31 October 2016); https://doi.org/10.1117/12.2245681

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KEYWORDS

Monte Carlo methods

Blood vessels

Absorption

Tissues

Blood

Photoacoustic microscopy

In vivo imaging

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