Compact LED-based full-field optical coherence microscopy for high-resolution high-speed in vivo imaging

Jonas Ogien; Arnaud Dubois

doi:10.1117/12.2254347

17 February 2017 Compact LED-based full-field optical coherence microscopy for high-resolution high-speed in vivo imaging

Jonas Ogien, Arnaud Dubois

Author Affiliations +

Proceedings Volume 10053, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI; 100532M (2017) https://doi.org/10.1117/12.2254347
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

This work reports on a compact full-field optical coherence microscopy (FF-OCM) setup specifically designed to meet the needs for in vivo imaging, illuminated by a high-brightness broadband light emitting diode (LED). Broadband LEDs have spectra potentially large enough to provide imaging spatial resolutions similar to those reached using conventional halogen lamps, but their radiance can be much higher, which leads to high speed acquisition and makes in vivo imaging possible. We introduce a FF-OCM setup using a 2.3 W broadband LED, with an interferometer designed to be as compact as possible in order to provide the basis for a portable system that will make it possible to fully benefit from the capacity for in vivo imaging by providing the ability to image any region of interest in real-time. The interferometer part of the compact FF-OCM setup weighs 210 g for a size of 11x11x5 cm³. Using this setup, a sub-micron axial resolution was reached, with a detection sensitivity of 68 dB at an imaging rate of 250 Hz. Due to the high imaging rate, the sensitivity could be improved by accumulation while maintaining an acquisition time short enough for in vivo imaging. It was possible to reach a sensitivity of 75 dB at a 50 Hz imaging rate. High resolution in vivo human skin images were obtained with this setup and compared with images of excised human skin, showing high similarity.

Citation Download Citation

Jonas Ogien and Arnaud Dubois "Compact LED-based full-field optical coherence microscopy for high-resolution high-speed in vivo imaging", Proc. SPIE 10053, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI, 100532M (17 February 2017); https://doi.org/10.1117/12.2254347

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available