Structural and functional imaging for vascular targeted photodynamic therapy

Buhong Li; Ying Gu; Brian C. Wilson

doi:10.1117/12.2253802

20 February 2017 Structural and functional imaging for vascular targeted photodynamic therapy

Buhong Li, Ying Gu, Brian C. Wilson

Proceedings Volume 10065, Biophotonics and Immune Responses XII; 1006504 (2017) https://doi.org/10.1117/12.2253802
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Vascular targeted photodynamic therapy (V-PDT) has been widely used for the prevention or treatment of vascular-related diseases, such as localized prostate cancer, wet age-related macular degeneration, port wine stains, esophageal varices and bleeding gastrointestinal mucosal lesions. In this study, the fundamental mechanisms of vascular responses during and after V-PDT will be introduced. Based on the V-PDT treatment of blood vessels in dorsal skinfold window chamber model, the structural and functional imaging, which including white light microscopy, laser speckle imaging, singlet oxygen luminescence imaging, and fluorescence imaging for evaluating vascular damage will be presented, respectively. The results indicate that vessel constriction and blood flow dynamics could be considered as the crucial biomarkers for quantitative evaluation of vascular damage. In addition, future perspectives of non-invasive optical imaging for evaluating vascular damage of V-PDT will be discussed.

Conference Presentation

Citation Download Citation

Buhong Li, Ying Gu, and Brian C. Wilson "Structural and functional imaging for vascular targeted photodynamic therapy", Proc. SPIE 10065, Biophotonics and Immune Responses XII, 1006504 (20 February 2017); https://doi.org/10.1117/12.2253802

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available