Electrical and optical co-stimulation in the deaf white cat

Zhiping Cao; Yingyue Xu; Xiaodong Tan; Naofumi Suematsu; Alan Robinson; Claus-Peter Richter

doi:10.1117/12.2291839

12 February 2018 Electrical and optical co-stimulation in the deaf white cat

Zhiping Cao, Yingyue Xu, Xiaodong Tan, Naofumi Suematsu, Alan Robinson, Claus-Peter Richter

Proceedings Volume 10469, Optical Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2018; 104690U (2018) https://doi.org/10.1117/12.2291839
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Spatial selectivity of neural stimulation with photons, such as infrared neural stimulation (INS) is higher than the selectivity obtained with electrical stimulation. To obtain more independent channels for stimulation in neural prostheses, INS may be implemented to better restore the fidelity of the damaged neural system. However, irradiation with infrared light also bares the risk of heat accumulation in the target tissue with subsequent neural damage. Lowering the threshold for stimulation could reduce the amount of heat delivered to the tissue and the risk for subsequent tissue damage. It has been shown in the rat sciatic nerve that simultaneous irradiation with infrared light and the delivery of biphasic sub-threshold electrical pulses can reduce the threshold for INS [1]. In this study, deaf white cats have been used to test whether opto-electrical co-stimulation can reduce the stimulation threshold for INS in the auditory system too. The cochleae of the deaf white cats have largely reduced spiral ganglion neuron counts and significant degeneration of the organ of Corti and do not respond to acoustic stimuli. Combined electrical and optical stimulation was used to demonstrate that simultaneous stimulation with infrared light and biphasic electrical pulses can reduce the threshold for stimulation.

Citation Download Citation

Zhiping Cao, Yingyue Xu, Xiaodong Tan, Naofumi Suematsu, Alan Robinson, and Claus-Peter Richter "Electrical and optical co-stimulation in the deaf white cat", Proc. SPIE 10469, Optical Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2018, 104690U (12 February 2018); https://doi.org/10.1117/12.2291839

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