New advances in RCM-OCT imaging for non-melanoma skin cancer detection and therapy guidance (Conference Presentation)

Nicusor V. Iftimia; Gopi N. Maguluri; Jesung Park; William J. Fox; Milind Rajadhyaksha

doi:10.1117/12.2291031

14 March 2018 New advances in RCM-OCT imaging for non-melanoma skin cancer detection and therapy guidance (Conference Presentation)

Nicusor V. Iftimia, Gopi N. Maguluri, Jesung Park, William J. Fox, Milind Rajadhyaksha

Author Affiliations +

Proceedings Volume 10489, Optical Biopsy XVI: Toward Real-Time Spectroscopic Imaging and Diagnosis; 104890S (2018) https://doi.org/10.1117/12.2291031
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

In this paper we summarize our recent advances in the development of a combined optical coherence tomography (OCT)/ reflectance confocal microscopy (RCM) approach for diagnosing non-melanoma skin cancers and guiding laser ablation therapy. After developing and clinically demonstrating a hand-held probe [1], our current focus is in adding the capability for generating rapid mosaic images of large areas of the skin (~15 mm x 15mm), as well as on developing a post-processing software that allows for rapid 3-D rendering of the collected data. We are also developing an automated segmentation algorithm that might be used to more objectively assess the depth of the non-melanoma tumors. With these capabilities, our integrated RCM and OCT imaging approach will provide 3-D microscopic views in orthogonally oriented and enfaceoriented planes with a range of resolutions and fields of view, which should further advance optical imaging to noninvasively guide both diagnosis as well as therapy of non-melanoma skin cancers. [1]. N. Iftimia et al., Handheld optical coherence tomography–reflectance confocal microscopy probe for detection of basal cell carcinoma and delineation of margins. J. Biomed. Opt. 22(7), 076006

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Nicusor V. Iftimia, Gopi N. Maguluri, Jesung Park, William J. Fox, and Milind Rajadhyaksha "New advances in RCM-OCT imaging for non-melanoma skin cancer detection and therapy guidance (Conference Presentation)", Proc. SPIE 10489, Optical Biopsy XVI: Toward Real-Time Spectroscopic Imaging and Diagnosis, 104890S (14 March 2018); https://doi.org/10.1117/12.2291031

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KEYWORDS

Skin cancer

3D image processing

Algorithm development

Confocal microscopy

Optical coherence tomography

Skin

Software development

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