Assessment of tissues' inhomogeneous optical properties by a cost-effective microscope based on LED illumination

Yinxu Bian; Qiulan Liu; Cuifang Kuang; Haifeng Li

doi:10.1117/12.2501126

23 October 2018 Assessment of tissues' inhomogeneous optical properties by a cost-effective microscope based on LED illumination

Yinxu Bian, Qiulan Liu, Cuifang Kuang, Haifeng Li

Author Affiliations +

Proceedings Volume 10820, Optics in Health Care and Biomedical Optics VIII; 108202O (2018) https://doi.org/10.1117/12.2501126
Event: SPIE/COS Photonics Asia, 2018, Beijing, China

Abstract

Assessing tissues’ inhomogeneous optical properties is helpful for diagnosis, but high-cost measurement and experimental setups limit its development, data collecting and applications. In this paper, a portable microscope is proposed to assess the inhomogeneous optical properties of the sample. With a LED illumination, accurate quantitative phase (QP) map can be recovered from 5 intensity images captured at different axial positions. Then based on the scattering-phase theorem and statistical dispersion relation (SDR), the inhomogeneous optical properties of the sample can be quantitatively assessed from these QP maps. In contrast to DHM and SLIM, our setup is cost-effective, use-flexible, and with a small amount of data acquisition, thus having the potential to promote the development of assessing tissues’ inhomogeneous optical properties, especially in resource-limited areas.

Citation Download Citation

Yinxu Bian, Qiulan Liu, Cuifang Kuang, and Haifeng Li "Assessment of tissues' inhomogeneous optical properties by a cost-effective microscope based on LED illumination", Proc. SPIE 10820, Optics in Health Care and Biomedical Optics VIII, 108202O (23 October 2018); https://doi.org/10.1117/12.2501126

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