Real-time diffuse optical B-mode Imaging (DOBI) for cancer monitoring  (Conference Presentation)

Matthew Applegate; Darren Roblyer

doi:10.1117/12.2508880

4 March 2019 Real-time diffuse optical B-mode Imaging (DOBI) for cancer monitoring (Conference Presentation)

Matthew Applegate, Darren Roblyer

Author Affiliations +

Proceedings Volume 10874, Optical Tomography and Spectroscopy of Tissue XIII; 108741K (2019) https://doi.org/10.1117/12.2508880
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Typical treatment for locally advanced breast cancer includes pre-surgical chemotherapy treatment to enable breast conserving surgery. Some patients, however, do not respond to chemotherapy, and endure months of treatment and unpleasant side-effects with no benefit. Near infrared spectroscopy is emerging as a promising candidate to differentiate patients responding to treatment from non-responders. Frequency-domain diffuse optical spectroscopy (FD-DOS) is capable of measuring concentrations of oxy-, and deoxyhemoglobin, lipid, and water in biological tissue. Changes in these concentrations over the course of chemotherapy can help predict a patient’s chemotherapy response. Most FD-DOS systems either use manually positioned, handheld probes, or complex arrays of source and detector fibers to acquire data from many tissue locations, allowing for the generation of 2D or 3D maps of tissue. Here, we present a new method to rapidly acquire a wide range of source-detector separations via high-speed mechanical scanning of a single source-detector pair. The scanning pattern chosen allows for the generation of axial line images of chromophore concentrations while the probe is stationary. Linear translation of the probe results in B-mode images that are capable of measuring the size and location of an absorbing inhomogeneity such as a tumor. Recently developed high speed acquisition electronics allow DOS data to be collected at nearly 100 Hz resulting in an a-line rate of 2-4 Hz. By utilizing a Deep Neural Network to estimate chromophore concentrations from the raw data, clinically relevant, depth resolved diffuse optical images of human tissue can be presented in real-time.

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Matthew Applegate and Darren Roblyer "Real-time diffuse optical B-mode Imaging (DOBI) for cancer monitoring (Conference Presentation)", Proc. SPIE 10874, Optical Tomography and Spectroscopy of Tissue XIII, 108741K (4 March 2019); https://doi.org/10.1117/12.2508880

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KEYWORDS

Cancer

Diffuse optical imaging

Optical imaging

Data acquisition

Tissue optics

Chromophores

Tissues

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