Resolution-enhancement of photoacoustic microscopy by modulation quenching of nanoparticles

Gregor Langer; Patricia M. A. Farias; Andreas Stingl; Raquel Milani; Bianca Buchegger; Jaroslaw Jacak; Andre Galembeck; Thomas A. Klar; Thomas Berer

doi:10.1117/12.2510230

27 February 2019 Resolution-enhancement of photoacoustic microscopy by modulation quenching of nanoparticles

Gregor Langer, Patricia M. A. Farias, Andreas Stingl, Raquel Milani, Bianca Buchegger, Jaroslaw Jacak, Andre Galembeck, Thomas A. Klar, Thomas Berer

Author Affiliations +

Proceedings Volume 10878, Photons Plus Ultrasound: Imaging and Sensing 2019; 1087822 (2019) https://doi.org/10.1117/12.2510230
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

In this work, we theoretically and experimentally deal with photoacoustic resolution enhancement by means of saturated modulation quenching. It is shown that experimental systems for resolution enhancement with saturated modulation quenching in fluorescence microscopy are not necessarily suited for photoacoustic modulation quenching. Here, we show that modulation quenching is not limited to fluorescent dyes but can be also applied to metallic nanoparticles. For modulation quenching in photoacoustic microscopy it is sufficient that the signal saturates with increasing excitation intensity.

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Gregor Langer, Patricia M. A. Farias, Andreas Stingl, Raquel Milani, Bianca Buchegger, Jaroslaw Jacak, Andre Galembeck, Thomas A. Klar, and Thomas Berer "Resolution-enhancement of photoacoustic microscopy by modulation quenching of nanoparticles", Proc. SPIE 10878, Photons Plus Ultrasound: Imaging and Sensing 2019, 1087822 (27 February 2019); https://doi.org/10.1117/12.2510230

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