Towards accurate and label-free monitoring of bio-analytes using supercontinuum based multispectral photoacoustic spectroscopy in the extended near-infrared wavelength regime

Manoj Kumar Dasa; Christos Markos; Jakob Janting; Abubakar I. Adamu; Patrick Bowen; Ole Bang

doi:10.1117/12.2510284

4 March 2019 Towards accurate and label-free monitoring of bio-analytes using supercontinuum based multispectral photoacoustic spectroscopy in the extended near-infrared wavelength regime

Manoj Kumar Dasa, Christos Markos, Jakob Janting, Abubakar I. Adamu, Patrick Bowen, Ole Bang

Author Affiliations +

Proceedings Volume 10890, Label-free Biomedical Imaging and Sensing (LBIS) 2019; 108900W (2019) https://doi.org/10.1117/12.2510284
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

In this work, we report a cost-effective supercontinuum (SC) laser-based multispectral photoacoustic spectroscopy (MSPAS) system for studying spectral characteristics of various analytes. We demonstrate an in vitro label-free monitoring of the analytes in the extended near-infrared (NIR) (1540–1840 nm) spectral range. We further demonstrate how a simple ratiometric analysis in conjunction with linear regression can be used for accurate prediction of glucose over commonly encountered physiological levels inside the human body (0–400 mg/dL). Looking forward, the proposed SC-based MSPAS system provides a framework for the development of label-free and non-invasive monitoring multiple bio-analytes accurately, with potential translation to clinical in vivo applications.

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Manoj Kumar Dasa, Christos Markos, Jakob Janting, Abubakar I. Adamu, Patrick Bowen, and Ole Bang "Towards accurate and label-free monitoring of bio-analytes using supercontinuum based multispectral photoacoustic spectroscopy in the extended near-infrared wavelength regime", Proc. SPIE 10890, Label-free Biomedical Imaging and Sensing (LBIS) 2019, 108900W (4 March 2019); https://doi.org/10.1117/12.2510284

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