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Bone defect is a common clinical disease, regeneration and repair of the damaged hard tissue is still a huge challenge in the biomedical field. In recent years, rare earth ion doped apatite upconversion luminescent nanomaterials have wide application prospects in tracing the situation of repair the damaged hard tissue and bioimaging due to their unique physical and chemical properties. The focus of this study is to further improve the luminous property of apatite upconversion nano materials for biomedicine. Rare earth ions Yb3+/Ho3+ doped nano-fluorapatite (FA: Yb3+/Ho3+) were prepared successfully by hydrothermal method. Transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier Transform Infrared Spectrometer (FTIR), fluorescence spectroscopy were used to characterization the morphology, crystal structure, chemical composition, and luminescence properties of Yb3+/Ho3+ doped nano-fluorapatite. The results showed that Yb3+/Ho3+ doped nano-hydroxyapatite material rod-shaped and has a hexagonal crystal structure. By adjusting the doped proportion of the rare earth Yb3+ and Ho3+ ions, upconversion luminescence efficiency of the material has greatly improved. The strongest emitting of FA: Yb3+/Ho3+ nanomaterials is when the doped proportion of the rare earth Yb3+ ions reach to 60% and Ho3+ ions reach to 3%. Thus, this kind of FA: Yb3+/Ho3+ nanomaterials have good upconversion luminescence properties can provide favorable conditions in cell markers and imaging. It is expected to promote their wider application in the biomedical field.
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