Strategies to enhance the sensitivity of NaGdF4:Yb-Tm based nanothermometers

Daria V. Pominova; Vera Yu. Proydakova; Igor D. Romanishkin; Anastasiya V. Ryabova; Pavel V. Grachev; Sergey V. Kuznetsov; Valerii V. Voronov; Pavel P. Fedorov

doi:10.1117/12.2523177

3 June 2019 Strategies to enhance the sensitivity of NaGdF₄:Yb-Tm based nanothermometers

Daria V. Pominova, Vera Yu. Proydakova, Igor D. Romanishkin, Anastasiya V. Ryabova, Pavel V. Grachev, Sergey V. Kuznetsov, Valerii V. Voronov, Pavel P. Fedorov

Author Affiliations +

Proceedings Volume 11067, Saratov Fall Meeting 2018: Computations and Data Analysis: from Nanoscale Tools to Brain Functions; 110671B (2019) https://doi.org/10.1117/12.2523177
Event: International Symposium on Optics and Biophotonics VI: Saratov Fall Meeting 2018, 2018, Saratov, Russian Federation

Abstract

The Yb³⁺-Tm³⁺-doped NaGdF₄ upconversion nanoparticles were studied as contactless nanothermometers for the first biological tissue transparency window under 980 nm excitation. The single hexagonal phase NaGdF₄:Yb³⁺-Tm³⁺ nanoparticles were synthesized by solvothermal technique. The influence of dopants concentration and pumping power density on thermal sensitivity and temperature resolution of obtained nanoparticles was analyzed. It was shown, that an increase of Yb³⁺ doping concentration leads to a strong increase in near-infrared Tm³⁺ luminescence intensity, which corresponds to transitions ³F₂-³H₆, ³F₃-³H₆, ³H₄-³H₆ and could be used for thermometry. The measured efficiency of upconversion luminescence for 80% of Yb³⁺ and 2% of Tm³⁺ doped nanoparticles was 5.0% compared to 0.2% efficiency for 30% of Yb³⁺ and 0.5% of Tm³⁺ doped nanoparticles. Laser induced heating of synthesized nanoparticles with ratiometric temperature measurement was studied. The increase of pumping power density negatively affected the sensitivity, but increased the accuracy of measurement due to the increased near-infrared luminescence. In addition, the comparison of different wavelengths for ratiometric thermal calibration was performed. It was shown, that the use of 680-720 nm luminescence peak to 730-750 nm valley intensity ratio for thermometry promotes significant enhancement of thermal sensitivity and temperature resolution. Thermal sensitivity of 4%∙C^-1 and temperature resolution of 0.6˚C in 30-36˚C region were obtained for NaGdF₄ nanoparticles doped with 80% of Yb³⁺ and 2% of Tm³⁺.

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Daria V. Pominova, Vera Yu. Proydakova, Igor D. Romanishkin, Anastasiya V. Ryabova, Pavel V. Grachev, Sergey V. Kuznetsov, Valerii V. Voronov, and Pavel P. Fedorov "Strategies to enhance the sensitivity of NaGdF₄:Yb-Tm based nanothermometers", Proc. SPIE 11067, Saratov Fall Meeting 2018: Computations and Data Analysis: from Nanoscale Tools to Brain Functions, 110671B (3 June 2019); https://doi.org/10.1117/12.2523177

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