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9 March 2020 In vivo quantification of Bruch's membrane in humans with visible light OCT (Conference Presentation)
Tingwei Zhang, Aaron Kho, Vyas Akondi, Alfredo Dubra, Vivek Srinivasan
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Proceedings Volume 11218, Ophthalmic Technologies XXX; 112180H (2020) https://doi.org/10.1117/12.2546437
Event: SPIE BiOS, 2020, San Francisco, California, United States
Abstract
Bruch’s membrane (BM) and retinal pigment epithelium (RPE) changes, thought to be the earliest signs of impending atrophy in dry age-related macular degeneration (AMD), are subtle and challenging to detect non-invasively. Here, we demonstrate imaging and quantification of BM and RPE thickness in the in vivo human eye using achromatized visible light optical coherence tomography (OCT) in normal human subjects. Our consistent visualization of BM and agreement of thickness values with ranges from prior histological studies is attributed to the increased axial resolution, and potentially also to the enhanced contrast of BM in the visible light range.
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Tingwei Zhang, Aaron Kho, Vyas Akondi, Alfredo Dubra, and Vivek Srinivasan "In vivo quantification of Bruch's membrane in humans with visible light OCT (Conference Presentation)", Proc. SPIE 11218, Ophthalmic Technologies XXX, 112180H (9 March 2020); https://doi.org/10.1117/12.2546437
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KEYWORDS
In vivo imaging
Optical coherence tomography
Visible radiation
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