Retinal pigment epithelium-melanin specific contrast imaging by multi-contrast OCT

Masahiro Miura; Shuichi Makita; Shinnosuke Azuma; Yoshiaki Yasuno; Toshihiro Mino; Tatsuo Yamaguchi; Satoshi Sugiyama; Takuya Iwasaki

doi:10.1117/12.2542922

19 February 2020 Retinal pigment epithelium-melanin specific contrast imaging by multi-contrast OCT

Masahiro Miura, Shuichi Makita, Shinnosuke Azuma, Yoshiaki Yasuno, Toshihiro Mino, Tatsuo Yamaguchi, Satoshi Sugiyama, Takuya Iwasaki

Author Affiliations +

Proceedings Volume 11218, Ophthalmic Technologies XXX; 112181H (2020) https://doi.org/10.1117/12.2542922
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

We used multi-contrast OCT (MC-OCT), which is capable of the simultaneous measurement of OCT angiography, degree of polarization uniformity and intensity OCT, to evaluate retinal pigment epithelium (RPE) changes. MC-OCT system was operated at an axial scan speed of 100,000 A-scans/s, using a swept-source laser at a central wavelength of 1,048 nm. From the dataset of MC-OCT, a pixel-wise segmentation method for RPE-melanin was developed and used to create RPE-melanin-specific contrast images to evaluate RPE-melanin changes. The RPE-melanin cross-sectional images were generated to evaluate the depth-resolved distribution of RPE-melanin. RPE-melanin thickness maps were created by counting the number of pixels with RPE-melanin at each A-line in the 3D dataset. An RPE-melanin thickness map represents the en face distribution of the thickness of RPE-melanin. We evaluated 37 eyes with age-related macular degeneration (AMD) with serous retinal pigment epithelium detachment, and 24 eyes with chronic Vogt-Koyanagi- Harada (VKH) disease. In these cases, RPE-melanin thickness maps showed similarities to the near infrared autofluorescence (NIR-AF; excitation 780 nm) images. In the eyes with AMD, focal RPE damages could be readily detected with RPE-melanin thickness map. RPE-melanin cross-sectional images were more sensitive for the damage at RPE-Bruch’s membrane band than intensity OCT images. In the eyes with VKH disease, RPE-melanin-specific contrast images clearly showed focal RPE-melanin accumulation at granular hyper NIR-AF lesions. In conclusion, this study demonstrated the clinical usefulness of RPE-melanin specific contrast OCT imaging for evaluating RPE changes in retinal diseases.

Conference Presentation

Citation Download Citation

Masahiro Miura, Shuichi Makita, Shinnosuke Azuma, Yoshiaki Yasuno, Toshihiro Mino, Tatsuo Yamaguchi, Satoshi Sugiyama, and Takuya Iwasaki "Retinal pigment epithelium-melanin specific contrast imaging by multi-contrast OCT", Proc. SPIE 11218, Ophthalmic Technologies XXX, 112181H (19 February 2020); https://doi.org/10.1117/12.2542922

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available