Photo-released drugs: a targeted treatment approach for arthritis

Victoria Wickenheisser; Emilia M. Zywot; Emily Rabjohns; Natalia Orlova; Christina M. Marvin; Song Ding; David S. Lawrence; Teresa R. Tarrant

doi:10.1117/12.2546949

19 February 2020 Photo-released drugs: a targeted treatment approach for arthritis

Victoria Wickenheisser, Emilia M. Zywot, Emily Rabjohns, Natalia Orlova, Christina M. Marvin, Song Ding, David S. Lawrence, Teresa R. Tarrant

Author Affiliations +

Proceedings Volume 11223, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2020; 112230R (2020) https://doi.org/10.1117/12.2546949
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

We have developed a technology that facilitates the targeted delivery of glucocorticoids to arthritic joints thereby side-stepping systemic immune suppression while potentially improving efficacy. Our technology loads phototherapeutics inside of red blood cell (RBC) carriers. This ensures that the inactive, RBC-contained phototherapeutic drug is transported throughout the body and released from the RBC carrier only after triggered release by long-wavelength light. We have demonstrated that medications bound to vitamin B12 can be photo-released from RBCs using tissue penetrating, longwavelength red, far-red, and near infrared light in the collagen antibody-induced arthritis model.

Conference Presentation

Citation Download Citation

Victoria Wickenheisser, Emilia M. Zywot, Emily Rabjohns, Natalia Orlova, Christina M. Marvin, Song Ding, David S. Lawrence, and Teresa R. Tarrant "Photo-released drugs: a targeted treatment approach for arthritis", Proc. SPIE 11223, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2020, 112230R (19 February 2020); https://doi.org/10.1117/12.2546949

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