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10 March 2020 Eradication of broad-spectrum multi-drug fungal pathogens through photoinactivation of a detoxifying enzyme (Conference Presentation)
Pu-Ting Dong, Zeina Dagher, Yuewei Zhan, Jie Hui, Michael K. Mansour, Ji-Xin Cheng
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Proceedings Volume 11223, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2020; 112230U (2020) https://doi.org/10.1117/12.2546838
Event: SPIE BiOS, 2020, San Francisco, California, United States
Abstract
Candida auris, the deadly infectious fungus, was reported to infest nearly 60 hospitals and more than 90 nursing homes in New York City. Moreover, these fungal species have developed resistance to all three major anti-fungal drugs. Drug-resistant Candida spp. and other non-albicans have developed multi-drug resistance around the world. Here, we show that, through efficient photoinactivation of an essential detoxifying enzyme which exists in most of the fungal strains, we could achieve significant eradication of those pathogens by subsequent administration of low-concentration of hydrogen peroxide and antifungal drugs. Noteworthy, hydrogen peroxide or antifungal alone is not effective to eradicate them.
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Pu-Ting Dong, Zeina Dagher, Yuewei Zhan, Jie Hui, Michael K. Mansour, and Ji-Xin Cheng "Eradication of broad-spectrum multi-drug fungal pathogens through photoinactivation of a detoxifying enzyme (Conference Presentation)", Proc. SPIE 11223, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2020, 112230U (10 March 2020); https://doi.org/10.1117/12.2546838
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KEYWORDS
Pathogens
Hydrogen
Lung
Oxygen
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