X-ray luminescence imaging for small animals

Michael C. Lun; Wenxiang Cong; Md. Arifuzzaman; Meenakshi Ranasinghe; Sriparna Bhattacharya; Jeffrey Anker; Ge Wang; Changqing Li

doi:10.1117/12.2544601

25 February 2020 X-ray luminescence imaging for small animals

Michael C. Lun, Wenxiang Cong, Md. Arifuzzaman, Meenakshi Ranasinghe, Sriparna Bhattacharya, Jeffrey Anker, Ge Wang, Changqing Li

Author Affiliations +

Proceedings Volume 11224, Optics and Ionizing Radiation; 112240F (2020) https://doi.org/10.1117/12.2544601
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

X-ray luminescence imaging emerged for about a decade and combines both the high spatial resolution of x-ray imaging with the high measurement sensitivity of optical imaging, which could result in a great molecular imaging tool for small animals. So far, there are two types of x-ray luminescence computed tomography (XLCT) imaging. One uses a pencil beam x-ray for high spatial resolution at a cost of longer measurement time. The other uses cone beam x-ray to cover the whole mouse to obtain XLCT images at a very short time but with a compromised spatial resolution. Here we review these two methods in this paper and highlight the synthesized nanophosphors by different research groups.

We are building a focused x-ray luminescence tomography (FXLT) imaging system, developing a machinelearning based FXLT reconstruction algorithm, and synthesizing nanophosphors with different emission wavelengths. In this paper, we will report our current progress from these three aspects. Briefly, we mount all main components, including the focused x-ray tube, the fiber detector, and the x-ray tube and x-ray detector for a microCT system, on a rotary which is a heavy-duty ring track. A microCT scan will be performed before FXLT scan. For a FXLT scan, we will have four PMTs to measure four fiber detectors at two different wavelengths simultaneously for each linear scan position. We expect the spatial resolution of the FXLT imaging will be around 100 micrometers and a limit of detection of approximately 2 μg/mL (for Gd₂O₂S:Eu).

Citation Download Citation

Michael C. Lun, Wenxiang Cong, Md. Arifuzzaman, Meenakshi Ranasinghe, Sriparna Bhattacharya, Jeffrey Anker, Ge Wang, and Changqing Li "X-ray luminescence imaging for small animals", Proc. SPIE 11224, Optics and Ionizing Radiation, 112240F (25 February 2020); https://doi.org/10.1117/12.2544601

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