Creation of a non-contact, automated brain tumor detection device for use in brain tumor resection

Matthew B. Tucker; Suzanna Joseph; Weston Ross; Guangshen Ma; Pakawat Chongsathidkiet; Peter Fecci; Patrick Codd

doi:10.1117/12.2546603

17 February 2020 Creation of a non-contact, automated brain tumor detection device for use in brain tumor resection

Matthew B. Tucker, Suzanna Joseph, Weston Ross, Guangshen Ma, Pakawat Chongsathidkiet, Peter Fecci, Patrick Codd

Proceedings Volume 11225, Clinical and Translational Neurophotonics 2020; 112250C (2020) https://doi.org/10.1117/12.2546603
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

The ability to differentiate healthy and tumorous tissue is vital during the surgical removal of tumors. This ability is especially critical during neurosurgical tumor resection due to the risk associated with removing healthy brain tissue. In this paper, we present an epifluorescence spectroscopy guided device that is not only capable of autonomously classifying a region of tissue as tumorous or healthy in real-time–but is also able to differentiate between different tumor types. For this study, glioblastoma and melanoma were chosen as the two different tumor types. Six mice were utilized in each of the three classes (healthy, glioblastoma, melanoma) for a total of eighteen mice. A “one-vs-the-all” approach was used to create a multi-class classifier. The multi-class classifier was capable of classifying with 100% accuracy. Future work includes increasing the number of mice in each of the three tumor classes to create a more robust classifier and expanding the number of tumor types beyond glioblastoma and melanoma.

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Citation Download Citation

Matthew B. Tucker, Suzanna Joseph, Weston Ross, Guangshen Ma, Pakawat Chongsathidkiet, Peter Fecci, and Patrick Codd "Creation of a non-contact, automated brain tumor detection device for use in brain tumor resection", Proc. SPIE 11225, Clinical and Translational Neurophotonics 2020, 112250C (17 February 2020); https://doi.org/10.1117/12.2546603

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