Multiphoton holographic manipulation of neural populations activity (Conference Presentation)

Ian Oldenburg; Hayley Bounds; Hillel Adesnik

doi:10.1117/12.2551383

9 March 2020 Multiphoton holographic manipulation of neural populations activity (Conference Presentation)

Ian Oldenburg, Hayley Bounds, Hillel Adesnik

Proceedings Volume 11226, Neural Imaging and Sensing 2020; 112261B (2020) https://doi.org/10.1117/12.2551383
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Sensory perception involves the coordinated effort of thousands of intermingled neurons that act together in groups to amplify and strengthen perceptions. We developed a new approach to edit neural population codes in the cortex during behavior using spatiotemporally precise multiphoton optogenetics. These tools allow us to manipulate individual or groups of cells selected by their functional properties with the precision to write in particular trains of action potentials. We are using these tools to probe how different patterns of activity added to the mouse visual cortex change the overall firing patterns in the cortex, recruiting inhibition, and altering sensory representations.

Conference Presentation

Citation Download Citation

Ian Oldenburg, Hayley Bounds, and Hillel Adesnik "Multiphoton holographic manipulation of neural populations activity (Conference Presentation)", Proc. SPIE 11226, Neural Imaging and Sensing 2020, 112261B (9 March 2020); https://doi.org/10.1117/12.2551383

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