Erythrocyte aggregation stimulated by NaYF4:Er3+,Yb3+ upconversion nanoparticles

Anna Doronkina; Natalia Kazadaeva; Elena Sagaidachnaya; Irina Yanina; Alexander Skaptsov; Yulia Konyukhova; Alexander Pravdin; Vyacheslav Kochubey; Nikita Navolokin

doi:10.1117/12.2559853

9 April 2020 Erythrocyte aggregation stimulated by NaYF⁴:Er³⁺,Yb³⁺ upconversion nanoparticles

Anna Doronkina, Natalia Kazadaeva, Elena Sagaidachnaya, Irina Yanina, Alexander Skaptsov, Yulia Konyukhova, Alexander Pravdin, Vyacheslav Kochubey, Nikita Navolokin

Author Affiliations +

Proceedings Volume 11457, Saratov Fall Meeting 2019: Optical and Nano-Technologies for Biology and Medicine; 114570D (2020) https://doi.org/10.1117/12.2559853
Event: Saratov Fall Meeting 2019: VII International Symposium on Optics and Biophotonics, 2019, Saratov, Russian Federation

Abstract

When administered into the bloodstream, upconversion nanoparticles used in therapeutic / diagnostic purposes can affect red blood cells. In this work, using light optical microscopy, we show that the removal of citrate groups from the surface of NaYF₄: Er³⁺ , Yb³⁺ nanoparticles synthesized by the hydrothermal method prevents the formation of large clod-like aggregates from a suspension of washed rat erythrocytes incubated with the nanoparticles. However, the tendency toward a change in cell shape with an increase in nanoparticles concentration is still manifested.

Citation Download Citation

Anna Doronkina, Natalia Kazadaeva, Elena Sagaidachnaya, Irina Yanina, Alexander Skaptsov, Yulia Konyukhova, Alexander Pravdin, Vyacheslav Kochubey, and Nikita Navolokin "Erythrocyte aggregation stimulated by NaYF⁴:Er³⁺,Yb³⁺ upconversion nanoparticles", Proc. SPIE 11457, Saratov Fall Meeting 2019: Optical and Nano-Technologies for Biology and Medicine, 114570D (9 April 2020); https://doi.org/10.1117/12.2559853

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