1U.S. Food and Drug Administration (United States) 2The Univ. of Arizona (United States) 3Thomas Jefferson High School for Science and Technology (United States)
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The presence of round cystic and solid mass lesions identified at mammogram screenings account for a large number of recalls. These recalls can cause undue patient anxiety and increased healthcare costs. Since cystic masses are nearly always benign, accurate classification of these lesions would be allow a significant reduction in recalls. This classification is very difficult using conventional mammogram screening data, but this study explores the possibility of performing the task on dual-energy full field digital mammography (FFDM) data. Since clinical data of this type is not readily available, realistic simulated data with different sources of variation are used. With this data, a deep convolutional neural network (CNN) was trained and evaluated. It achieved an AUC of 0.980 and 42% specificity at the 99% sensitivity level. These promising results should motivate further development of such imaging systems.
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Brian Toner, Andrey Makeev, Marian Qian, Andreu Badal, Stephen J. Glick, "Classification of round lesions in dual-energy FFDM using a convolutional neural network: simulation study," Proc. SPIE 11595, Medical Imaging 2021: Physics of Medical Imaging, 115952C (15 February 2021); https://doi.org/10.1117/12.2582301