Photoacoustic identification of lipid patterns in advanced atherosclerotic plaques

Sophinese Iskander-Rizk; Mirjam Visscher; Astrid Moerman; Nuria Slijkhuis; Antonius F. W. van der Steen; Kim van der Heiden; Gijs van Soest

doi:10.1117/12.2577586

5 March 2021 Photoacoustic identification of lipid patterns in advanced atherosclerotic plaques

Sophinese Iskander-Rizk, Mirjam Visscher, Astrid Moerman, Nuria Slijkhuis, Antonius F. W. van der Steen, Kim van der Heiden, Gijs van Soest

Author Affiliations +

Proceedings Volume 11621, Diagnostic and Therapeutic Applications of Light in Cardiology 2021; 116210K (2021) https://doi.org/10.1117/12.2577586
Event: SPIE BiOS, 2021, Online Only

Abstract

Atherosclerosis is a disease characterized by the narrowing of the arteries as a result of plaque buildup. Lipid-rich plaques are hypothesized to be ‘vulnerable’ plaques with higher risks of rupture. In order to identify lipid biomarkers in-vivo, we use an in-house built photoacoustic imaging microscope system in tandem with mass spectrometer imaging for lipid full characterization. We show photoacoustic lipid spectra of sectioned human carotid endarterectomy samples on histological glass slides to unravel a photoacoustic lipid spectral histology ranging from 1140 nm to 1250 nm. We relate the spectral features identified by PAM to lipids found by mass spectrometry imaging.

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Sophinese Iskander-Rizk, Mirjam Visscher, Astrid Moerman, Nuria Slijkhuis, Antonius F. W. van der Steen, Kim van der Heiden, and Gijs van Soest "Photoacoustic identification of lipid patterns in advanced atherosclerotic plaques", Proc. SPIE 11621, Diagnostic and Therapeutic Applications of Light in Cardiology 2021, 116210K (5 March 2021); https://doi.org/10.1117/12.2577586

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