Optical physics-based methodology for quantifying Bruch’s membrane with visible light OCT

Tingwei Zhang; Aaron Kho; Robert Zawadzki; Ravi S. Jonnal; Glenn Yiu; Vivek Srinivasan

doi:10.1117/12.2577851

5 March 2021 Optical physics-based methodology for quantifying Bruch’s membrane with visible light OCT

Tingwei Zhang, Aaron Kho, Robert Zawadzki, Ravi S. Jonnal, Glenn Yiu, Vivek Srinivasan

Proceedings Volume 11623, Ophthalmic Technologies XXXI; 116231F (2021) https://doi.org/10.1117/12.2577851
Event: SPIE BiOS, 2021, Online Only

Abstract

Bruch’s membrane (BM) is a pentalaminar structure that mediates transport between the retinal pigment epithelium (RPE) and choriocapillaris. With near-infrared Optical Coherence Tomography (OCT), it has been challenging to visualize, let alone quantify, BM non-invasively in non-pathologic eyes. First, we show that shorter wavelength visible light OCT consistently delineates BM better than longer wavelength visible light OCT in pigmented human subjects, independent of axial resolution. Second, we develop a physical model of RPE and BM reflectivity to explain this finding. Third, we employ this model to devise a morphometric algorithm to more accurately map BM thickness in the normal macula.

Conference Presentation

Citation Download Citation

Tingwei Zhang, Aaron Kho, Robert Zawadzki, Ravi S. Jonnal, Glenn Yiu, and Vivek Srinivasan "Optical physics-based methodology for quantifying Bruch’s membrane with visible light OCT", Proc. SPIE 11623, Ophthalmic Technologies XXXI, 116231F (5 March 2021); https://doi.org/10.1117/12.2577851

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