Cracking hypothalamic circuits that drive survival behaviors using novel optical methods

Yeka Aponte

doi:10.1117/12.2595861

7 March 2021 Cracking hypothalamic circuits that drive survival behaviors using novel optical methods

Yeka Aponte

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Proceedings Volume 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics; 1162904 (2021) https://doi.org/10.1117/12.2595861
Event: SPIE BiOS, 2021, Online Only

Abstract

Functional imaging in vivo has become a powerful tool for studying neuronal circuits during behavior. Here we use a microendoscopy system for deep-brain imaging from two distinct lateral hypothalamic neuron populations (i.e. LHPV and LHLEPR). By combining endomicroscopy, genetically encoded calcium indicators, optogenetics, and chemogenetics, we demonstrate that LHPV neurons modulate pain whereas LHLEPR neuronal activity encodes for appetitive behaviors in mice.

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Yeka Aponte "Cracking hypothalamic circuits that drive survival behaviors using novel optical methods", Proc. SPIE 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics, 1162904 (7 March 2021); https://doi.org/10.1117/12.2595861

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