Effect of blood transfusion on cerebral hemodynamics measured by diffuse optical spectroscopies

Seung Yup Lee; Eashani Sathialingam; Kyle R. Cowdrick; R. Clark Brown; Clinton H. Joiner; Erin M. Buckley

doi:10.1117/12.2578688

5 March 2021 Effect of blood transfusion on cerebral hemodynamics measured by diffuse optical spectroscopies

Seung Yup Lee, Eashani Sathialingam, Kyle R. Cowdrick, R. Clark Brown, Clinton H. Joiner, Erin M. Buckley

Proceedings Volume 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics; 116291D (2021) https://doi.org/10.1117/12.2578688
Event: SPIE BiOS, 2021, Online Only

Abstract

Blood transfusion therapy is the current standard of care to reduce elevated risk of primary and recurrent strokes in children with sickle cell disease. Despite great success, chronic transfusion is not without significant risks and comes with a substantial burden. Individualized cerebral monitoring for goal-oriented therapy may better ensure optimal response to treatment and further mitigate risk of infarctions. In this study, we demonstrate diffuse optical spectroscopies (Diffuse Correlation Spectroscopy and Frequency-Domain Near-infrared Spectroscopy) as a simple and low-cost means for bedside assessments of changes in cerebral blood flow, oxygen extraction, and metabolic rate of oxygen in response to transfusion.

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Seung Yup Lee, Eashani Sathialingam, Kyle R. Cowdrick, R. Clark Brown, Clinton H. Joiner, and Erin M. Buckley "Effect of blood transfusion on cerebral hemodynamics measured by diffuse optical spectroscopies", Proc. SPIE 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics, 116291D (5 March 2021); https://doi.org/10.1117/12.2578688

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KEYWORDS

Diffuse optical spectroscopy

Hemodynamics

Blood

Optical testing

Near infrared spectroscopy

Cerebral blood flow

Ionizing radiation

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