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We have developed hybrid femtosecond laser processing for fabrication of 3D microfluidic SERS chips. The resulting chip can perform the real-time SERS detection of Cd2+ ions at concentrations as low as 10 ppb. We have further proposed a novel strategy by taking advantage of the microfluidic configuration. The microfluidic chip can produce an interface of analyte solution and air on the SERS substrate in the microfluidic channel, which locally aggregates the analyte molecules at the interface during the measurements (LI-SERS). The LI-SERS technique achieves the analytical enhancement factor reaching 1.5 × 10^14 with a detection limit below 10 aM.
Koji Sugioka andFelix Sima
"3D glass nanofluidics fabricated by femtosecond laser processing for study on cancer cell metastasis", Proc. SPIE 11637, Microfluidics, BioMEMS, and Medical Microsystems XIX, 116370T (5 March 2021); https://doi.org/10.1117/12.2590777
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Koji Sugioka, Felix Sima, "3D glass nanofluidics fabricated by femtosecond laser processing for study on cancer cell metastasis," Proc. SPIE 11637, Microfluidics, BioMEMS, and Medical Microsystems XIX, 116370T (5 March 2021); https://doi.org/10.1117/12.2590777