Polymer-based spherical matrix array for high resolution real-time volumetric optoacoustic micro-angiography

Pavel Subochev; Xosé Luís Deán-Ben; Zhenyue Chen; Anna Orlova; Daniel Razansky

doi:10.1117/12.2579204

5 March 2021 Polymer-based spherical matrix array for high resolution real-time volumetric optoacoustic micro-angiography

Pavel Subochev, Xosé Luís Deán-Ben, Zhenyue Chen, Anna Orlova, Daniel Razansky

Author Affiliations +

Proceedings Volume 11642, Photons Plus Ultrasound: Imaging and Sensing 2021; 116421V (2021) https://doi.org/10.1117/12.2579204
Event: SPIE BiOS, 2021, Online Only

Abstract

Optoacoustic (OA) tomography has recently demonstrated ultrafast imaging rates, owing to its unique ability to capture volumetric image data with a single nanosecond-duration flash of light. The achievable spatial resolution of volumetric tomography is however limited by the narrow bandwidth and lack of scalability of the piezo-composite arrays currently employed for OA signal detection. Here we report on the first implementation of high-density spherical matrix array technology based on flexible polyvinylidene difluoride films featuring ultrawideband (38 MHz) sub-millimeter sized elements thus enabling volumetric imaging with ~35 μm resolution, superior image fidelity and excellent signal to noise performance permitting real-time imaging of deep tissues without employing signal averaging. We demonstrate real-time volumetric in vivo imaging capabilities of the new approach by performing cerebral angiography in mice. The new technology leverages the true potential of OA for high spatio-temporal resolution visualization of rapid biodynamics.

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Citation Download Citation

Pavel Subochev, Xosé Luís Deán-Ben, Zhenyue Chen, Anna Orlova, and Daniel Razansky "Polymer-based spherical matrix array for high resolution real-time volumetric optoacoustic micro-angiography", Proc. SPIE 11642, Photons Plus Ultrasound: Imaging and Sensing 2021, 116421V (5 March 2021); https://doi.org/10.1117/12.2579204

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