Comparing mechanisms of scatter in breast tumor tissues using sub-diffuse light scatter imaging and micro-computed tomography

Samuel S. Streeter; Benjamin W. Maloney; Wendy A. Wells; Keith D. Paulsen; Brian W. Pogue

doi:10.1117/12.2578265

5 March 2021 Comparing mechanisms of scatter in breast tumor tissues using sub-diffuse light scatter imaging and micro-computed tomography

Samuel S. Streeter, Benjamin W. Maloney, Wendy A. Wells, Keith D. Paulsen, Brian W. Pogue

Author Affiliations +

Proceedings Volume 11657, Biomedical Applications of Light Scattering XI; 116570G (2021) https://doi.org/10.1117/12.2578265
Event: SPIE BiOS, 2021, Online Only

Abstract

We examine the relative merits of wide-field, sub-diffuse light scatter imaging and micro-computed tomography for visualizing breast tumor heterogeneity. A large dataset of breast tumor slices was imaged using both modalities, and image data were spatially co-registered with histopathological images to facilitate direct comparisons in feature visualization between tissue types, including normal, benign, and malignant tissues, and microcalcifications. Mechanisms of scatter for the two modalities are discussed and related to the features detected by each modality.

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Samuel S. Streeter, Benjamin W. Maloney, Wendy A. Wells, Keith D. Paulsen, and Brian W. Pogue "Comparing mechanisms of scatter in breast tumor tissues using sub-diffuse light scatter imaging and micro-computed tomography", Proc. SPIE 11657, Biomedical Applications of Light Scattering XI, 116570G (5 March 2021); https://doi.org/10.1117/12.2578265

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