Detecting mouse glioma tissues with a terahertz time-domain spectroscopy technique

Yuansen Guo; Shi Wang; Tunan Chen; Hua Zhang; DanDan Li; Ning Mu; Huabin Wang

doi:10.1117/12.2605342

9 September 2021 Detecting mouse glioma tissues with a terahertz time-domain spectroscopy technique

Yuansen Guo, Shi Wang, Tunan Chen, Hua Zhang, DanDan Li, Ning Mu, Huabin Wang

Proceedings Volume 11909, Tenth International Symposium on Ultrafast Phenomena and Terahertz Waves (ISUPTW 2021); 119090L (2021) https://doi.org/10.1117/12.2605342
Event: Tenth International Symposium on Ultrafast Phenomena and Terahertz Waves (ISUPTW 2021), 2021, Chengdu, China

Abstract

Brain glioma is the most frequent primary tumor of the nervous system, and has serious adverse effects on public health and social economy. A technique that can be used to precisely detect glioma is highly demanded. Here, we report on that the terahertz time-domain spectroscopy, a rapid, label-free and non-destructive technique, was utilized to probe mouse tissue slices containing glioma. The results show that the glioma can be discriminated in the frequency range of 0.7-1.6 THz on the basis that the refractive index as well as the absorption coefficient of glioma are higher than the normal tissue, which can be attributed to the higher cell density and water content of the glioma. The present work validates that it is feasible to detect glioma with a terahertz time-domain spectroscopy technique.

Citation Download Citation

Yuansen Guo, Shi Wang, Tunan Chen, Hua Zhang, DanDan Li, Ning Mu, and Huabin Wang "Detecting mouse glioma tissues with a terahertz time-domain spectroscopy technique", Proc. SPIE 11909, Tenth International Symposium on Ultrafast Phenomena and Terahertz Waves (ISUPTW 2021), 119090L (9 September 2021); https://doi.org/10.1117/12.2605342

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KEYWORDS

Tissues

Terahertz radiation

Brain

Terahertz spectroscopy

Spectroscopy

Absorption

Refractive index

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