Implementation of a combined theranostic x-ray irradiator/fluorescence imaging system for automatic assessment of tumor vascular response to radiation therapy

Farouk Nouizi; Jamison Brooks; Darren M. Zuro; Susanta K. Hui; Gultekin Gulsen

doi:10.1117/12.2609168

4 March 2022 Implementation of a combined theranostic x-ray irradiator/fluorescence imaging system for automatic assessment of tumor vascular response to radiation therapy

Farouk Nouizi, Jamison Brooks, Darren M. Zuro, Susanta K. Hui, Gultekin Gulsen

Author Affiliations +

Proceedings Volume 11944, Multiscale Imaging and Spectroscopy III; 1194405 (2022) https://doi.org/10.1117/12.2609168
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Hypofractionated stereotactic body radiotherapy treatments (SBRT) have improved patient treatment outcomes. Extensive studies were performed investigating how vascular changes during treatment affect its efficacy. Unfortunately, histology is unable to perform non-invasive longitudinal assessments by directly measuring blood perfusion. Here, we present a novel preclinical theranostic μCT-guided irradiator/Fluorescence Molecular Imager, designed to perform a fast, non-invasive, and longitudinal assessment of tumor vascular response (TVR) to targeted radiotherapy. Our technique allows rapid assessment of spatiotemporal differences in indocyanine green (ICG) kinetics in tumors using principal component (PC) analysis, before and after tumor irradiation. Results show that changes were observed in the normalized first and second PC feature pixel values (p=0.0559, 0.0432 paired t-test). Moreover, we implemented a fast PC-based classification algorithm that yields spatially-resolved TVR maps. Our first-of-its-kind theranostic system, allowing automated assessment of TVR to SBRT, will be used to better understand the role of tumor perfusion in metastasis and tumor control.

Conference Presentation

Citation Download Citation

Farouk Nouizi, Jamison Brooks, Darren M. Zuro, Susanta K. Hui, and Gultekin Gulsen "Implementation of a combined theranostic x-ray irradiator/fluorescence imaging system for automatic assessment of tumor vascular response to radiation therapy", Proc. SPIE 11944, Multiscale Imaging and Spectroscopy III, 1194405 (4 March 2022); https://doi.org/10.1117/12.2609168

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available