PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
One of the most powerful technologies for single molecule fluorescence spectroscopy at concentrations which are close to biological processes (micro and millimolar) is based on the use of Zero Mode Waveguides (ZMWs). Standard ZMWs are prepared as nanoholes array in Al thin films. Although very efficient to enable single molecule detection, Al-ZMWs are not optimized in term of fluorescence emission. On the contrary an engineered configuration where alternative metals such as Au, Ag, Al, etc. are used can produce significant enhancement in the single molecule detection. Thanks to optimized designs can be possible to enhance the fluorescence emission not only in the visible spectral range but also in the Ultraviolet (UV) and Near-infrared (NIR). Here we discuss the major results on plasmonic ZMWs and their use in single molecule fluorescence.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
The alert did not successfully save. Please try again later.
Alemayehu Nana Koya, Antonietta Parracino, "Plasmonic zero mode waveguide for enhanced single molecule detection," Proc. SPIE 12131, Nanophotonics IX, 1213102 (24 May 2022); https://doi.org/10.1117/12.2622217