Comparative study of optical properties estimation on liquid optical phantoms using spatially-resolved diffuse reflectance spectroscopy and double integrating spheres methods

Victor Colas; Marine Amouroux; Christian Daul; Clarice Perrin-Mozet; Walter Blondel

doi:10.1117/12.2621496

19 May 2022 Comparative study of optical properties estimation on liquid optical phantoms using spatially-resolved diffuse reflectance spectroscopy and double integrating spheres methods

Victor Colas, Marine Amouroux, Christian Daul, Clarice Perrin-Mozet, Walter Blondel

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Proceedings Volume 12147, Tissue Optics and Photonics II; 1214705 (2022) https://doi.org/10.1117/12.2621496
Event: SPIE Photonics Europe, 2022, Strasbourg, France

Abstract

Whether for diagnosis, therapy or surgery, the estimation of optical properties (OP) of biological tissues is now of interest in the medical context. Indeed, optical methods are increasingly used in modern medicine, and these require knowledge of the behavior of light within the tissue. The presentation contribution aims to validate the estimation process of absorption and scattering coefficients values obtained using spatially-resolved diffuse reflectance (SR-DR) spectroscopy by comparing the obtained results with those of the reference double integrating spheres (DIS) technique. A set of nine optical phantoms based on methylene blue and intralipids allowing to tune absorption and scattering properties was prepared, from which diffuse reflectance spectra and integrating spheres measurements were acquired respectively. Work presented here reports both estimations approaches developed and highlights the relative spreads of optical properties between DR, DIS and theoretical values (i.e. according scatterer and absorber concentrations introduced in phantoms). This validation on optical bench will allow to later estimate the OP from in-vivo DR spectra acquired on skin samples, to assist the surgeon in non-invasively diagnosing the health status of a tissue around a skin carcinoma

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Victor Colas, Marine Amouroux, Christian Daul, Clarice Perrin-Mozet, and Walter Blondel "Comparative study of optical properties estimation on liquid optical phantoms using spatially-resolved diffuse reflectance spectroscopy and double integrating spheres methods", Proc. SPIE 12147, Tissue Optics and Photonics II, 1214705 (19 May 2022); https://doi.org/10.1117/12.2621496

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KEYWORDS

Optical phantoms

Inverse problems

Absorption

Scattering

Diffuse reflectance spectroscopy

Integrating spheres

Optical properties

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