Laser-induced thermal decomposition with Diffractive Lens Array (DLA) in ex vivo and in vivo skin tissue

Jiho Lee; Jongman Choi; Hyun Wook Kang

doi:10.1117/12.2648552

14 March 2023 Laser-induced thermal decomposition with Diffractive Lens Array (DLA) in ex vivo and in vivo skin tissue

Jiho Lee, Jongman Choi, Hyun Wook Kang

Proceedings Volume 12352, Photonics in Dermatology and Plastic Surgery 2023; 123520E (2023) https://doi.org/10.1117/12.2648552
Event: SPIE BiOS, 2023, San Francisco, California, United States

Conference Poster

Abstract

Laser skin treatment using micro-lens arrays (MLA) and diffractive optical elements (DOE) have clinically been applied to treat pigmented lesions [1,2]. However, DOE hardly has a deep penetration depth and MLA shows a non-uniform distribution of lesions, making it difficult to target lesions deeply located in the dermis [2]. The purpose of this study is to investigate the feasibility of diffractive lens arrays (DLA, combination of MLA and DOE) to treat the pigmented skin via laser-induced thermal decomposition at various tissue depth. Porcine skin tissue and one farm pig were used to compare spatial distributions of the laser-induced damage after irradiation with DOE, MLA, and DLA. 1064 nm picosecond Nd:YAG laser light was irradiated on a target tissue at 3.0 ~ 6.0 J/cm² under DOE, MLA, and DLA conditions. According to ex vivo tests, DOE generated laser-induced vacuoles near the basal membrane (208 ± 80 μm), and MLA distributed vacuoles more deeply located in dermis than DOE (382 ± 147 μm). On the other hand, DLA created laser-induced thermal decomposition deeply positioned in dermis (548 ± 137 μm). In vivo tests demonstrated that DOE generated the vacuolization in epidermis and dermis (235 ± 82 μm). On the other hand, DLA generated the deep laser-induced thermal decomposition in dermis (1057 ± 286 μm). The current study demonstrated that the picosecond laser irradiation with DLA could create the thermal decomposition in the deep dermis. Therefore, the DLA-assisted laser application may help to achieve selective skin treatment for deeply located pigments.

Citation Download Citation

Jiho Lee, Jongman Choi, and Hyun Wook Kang "Laser-induced thermal decomposition with Diffractive Lens Array (DLA) in ex vivo and in vivo skin tissue", Proc. SPIE 12352, Photonics in Dermatology and Plastic Surgery 2023, 123520E (14 March 2023); https://doi.org/10.1117/12.2648552

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