Evolution of ischemic stroke assessed with resting-state hemodynamics in mice

Brian R. White; Claudia Chan; Sabrina Da Silva; Evelyn K. Shih

doi:10.1117/12.2647757

17 March 2023 Evolution of ischemic stroke assessed with resting-state hemodynamics in mice

Brian R. White, Claudia Chan, Sabrina Da Silva, Evelyn K. Shih

Proceedings Volume 12364, Clinical and Translational Neurophotonics 2023; 123640O (2023) https://doi.org/10.1117/12.2647757
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Bedside tools are needed to alert clinicians to the onset of ischemic stroke. Resting-state hemodynamics with optical intrinsic signal imaging (OIS) were assessed in mice before and after middle cerebral artery (MCA) stroke. OIS analysis included resting-state functional connectivity (FC), low frequency power (LFP, local brain activity), and temporal-shift delay (impaired perfusion). Immediately after stroke, there is a decrease in homotopic connectivity and an absence of LFP in stroke-affected hemisphere; perfusion deficits were more localized. Over 24 hours, LFP and delayed perfusion localized in the core MCA territory (matching TTC staining). Such biomarker development could translate to optical bedside technologies.

Conference Presentation

Citation Download Citation

Brian R. White, Claudia Chan, Sabrina Da Silva, and Evelyn K. Shih "Evolution of ischemic stroke assessed with resting-state hemodynamics in mice", Proc. SPIE 12364, Clinical and Translational Neurophotonics 2023, 123640O (17 March 2023); https://doi.org/10.1117/12.2647757

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