Photonics probing of structural alterations in Alzheimer’s disease in human brain cells and tissues

Fatemah Alharthi; Ishmael Apachigawo; Mohammad Moshahid Khan; Prabhakar Pradhan

doi:10.1117/12.2650507

7 March 2023 Photonics probing of structural alterations in Alzheimer’s disease in human brain cells and tissues

Fatemah Alharthi, Ishmael Apachigawo, Mohammad Moshahid Khan, Prabhakar Pradhan

Proceedings Volume 12377, Optical Interactions with Tissue and Cells XXXIV; 123770E (2023) https://doi.org/10.1117/12.2650507
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Among the deadliest diseases in human history, Alzheimer's disease (AD) is a chronic neurodegenerative disorder that increases in seriousness over time. Changes in the brain start several decades before the development of AD, as an abnormal protein, beta-amyloid, start aggregating in the hippocampus area of the brain. At an early stage of AD, structural changes occur at the nanoscale level due to intracellular structural alterations. Hence, detecting nanoscale-level abnormalities early in the disease process is crucial for effective treatment. Dual optical/photonic techniques, Partial wave spectroscopy (PWS), and inverse participation ratio (IPR), are used to detect the nano to submicron scales structural alterations in the human brain cells/tissues due to AD.

Conference Presentation

Citation Download Citation

Fatemah Alharthi, Ishmael Apachigawo, Mohammad Moshahid Khan, and Prabhakar Pradhan "Photonics probing of structural alterations in Alzheimer’s disease in human brain cells and tissues", Proc. SPIE 12377, Optical Interactions with Tissue and Cells XXXIV, 123770E (7 March 2023); https://doi.org/10.1117/12.2650507

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