Understanding vascular and cellular activity during cerebral stroke in zebrafish model using swept-source optical coherence tomography/angiography (SSOCT/A)

Zoya Alam; Abhishek Banerjee; Robert J. Zawadzki; Raju Poddar

doi:10.1117/12.2656871

16 March 2023 Understanding vascular and cellular activity during cerebral stroke in zebrafish model using swept-source optical coherence tomography/angiography (SSOCT/A)

Zoya Alam, Abhishek Banerjee, Robert J. Zawadzki, Raju Poddar

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Proceedings Volume 12389, Quantitative Phase Imaging IX; 123890N (2023) https://doi.org/10.1117/12.2656871
Event: SPIE BiOS, 2023, San Francisco, California, United States

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Abstract

We present a non-invasive study of the zebrafish brain to understand the vasculature and changing cellular dynamics in the cerebral stroke model using swept-source optical coherence tomography/angiography (SSOCT/A). An ischemic stroke is caused by reduced or obstructed blood supply in the brain, eventually leading to cell death due to insufficient oxygen and nutrient levels. The aberrant/anomalous blood flow characteristics in ischemic stroke are analyzed by phase variance and the doppler method using SSOCT. The subsequent cell mortality is monitored using the speckle-contrast technique of SSOCT. The SSOCT technique for disease surveillance provides fast acquisition time, reduced motion artifacts, label-free visualization, and non-invasive examination.

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Zoya Alam, Abhishek Banerjee, Robert J. Zawadzki, and Raju Poddar "Understanding vascular and cellular activity during cerebral stroke in zebrafish model using swept-source optical coherence tomography/angiography (SSOCT/A)", Proc. SPIE 12389, Quantitative Phase Imaging IX, 123890N (16 March 2023); https://doi.org/10.1117/12.2656871

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