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Digital subtraction angiography (DSA) is a widely used technique for the visualization of contrast-enhanced structures. However, temporal subtraction DSA is challenged by misregistration artifacts due to patient motion and incomplete separation of iodine contrast agent from background soft tissue and bone. In this work, we propose an approach that allows three-material decomposition using a dual-layer flat panel detector in the presence of soft tissue motion. We assume the calcium signal (bone) remains stationary in the pre- and post-contrast images but allow soft tissues to move freely (e.g. cardiac motion). The dual-layer pre- and post-injection images form and ensemble of four measurements that permits material decomposition of four bases (pre- and post-injection soft tissue, calcium, and iodine). We apply two different processing techniques: 1) a modified lookup table and; 2) a model-based material estimation. These are compared with previously proposed DSA methods using temporal subtraction and hybrid (dual-energy) subtraction. Investigations were performed using an XCAT thorax phantom simulating a breath-hold. The pre- and post-contrast measurements were simulated at different time points within a cardiac cycle. Both the lookup table and model-based algorithms eliminate motion artifact as a result of soft tissue motion and allow good separation of iodine, bone, and soft tissue. While the lookup table algorithm contains high noise at the simulated dose level, the model-based algorithm produced iodine images that allow the visualization of major vessels around the heart. In contrast, traditional temporal DSA is susceptible to subtraction artifacts and hybrid DSA shows increased noise.
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