Investigating the effect of cerebral atrophy on brain deformation using subject-specific models

Allen Hong; Aaron Carass; Lianrui Zuo; Jerry L. Prince; Ahmed Alshareef

doi:10.1117/12.2654461

10 April 2023 Investigating the effect of cerebral atrophy on brain deformation using subject-specific models

Allen Hong, Aaron Carass, Lianrui Zuo, Jerry L. Prince, Ahmed Alshareef

Proceedings Volume 12468, Medical Imaging 2023: Biomedical Applications in Molecular, Structural, and Functional Imaging; 1246815 (2023) https://doi.org/10.1117/12.2654461
Event: SPIE Medical Imaging, 2023, San Diego, California, United States

Abstract

Traumatic brain injuries (TBIs) are a major health risk that increases with age. Natural brain aging results in cerebral atrophy and the enlargement of the ventricular regions. The objective of this study is to investigate the effect of cerebral atrophy on brain biomechanics with subject-specific models to determine the risk of traumatic brain injury (TBI). Utilizing subjects from a longitudinal study of aging in healthy volunteers, we created subject-specific brain models of a small cohort with progressive age-related cerebral atrophy. We then simulate concussive loading conditions to study changes in brain deformation, a correlate to risk of TBI. The results display differing trends with increasing ventricle volume, with some subjects exhibiting increases and others showing decreasing strain. Additional subject simulations are needed to clarify these the causes of these trends.

Conference Presentation

Citation Download Citation

Allen Hong, Aaron Carass, Lianrui Zuo, Jerry L. Prince, and Ahmed Alshareef "Investigating the effect of cerebral atrophy on brain deformation using subject-specific models", Proc. SPIE 12468, Medical Imaging 2023: Biomedical Applications in Molecular, Structural, and Functional Imaging, 1246815 (10 April 2023); https://doi.org/10.1117/12.2654461

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available