The role of P53 in cancer and infectious disease

Jiaxin Liu

doi:10.1117/12.2669658

24 March 2023 The role of P53 in cancer and infectious disease

Jiaxin Liu

Proceedings Volume 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022); 126113F (2023) https://doi.org/10.1117/12.2669658
Event: International Conference on Biological Engineering and Medical Science (ICBioMed2022), 2022, Oxford, United Kingdom

Abstract

The first discovery of p53 in humans was made 40 years ago when six research groups found a 53kDa protein in human and mouse cells. The reason is that the p53 protein binds to a large T antigen in SV40 infected cells. During the co-immunoprecipitation of antiserum against viral protein, the ratio of T antigen and p53 protein was found to remain unchanged. (1) Subsequently, p53 was also confirmed to be associated with Li-Fraumeni Syndrome (LFS). LFS is an inherited familial predisposition, which makes individuals affected by this genetic disease highly susceptible to tumors or cancer, and later proved to be caused by mutations in TP53. (2) Therefore, p53 was confirmed to be a tumor suppressor gene. With the development of nearly 40 years, the research of p53 has gradually matured, but there are still many gaps in its role in viral immune defense. However, according to the existing p53-related research, the p53 plays an extremely important role in human. Among various types of viruses, p53 can still regulate or affect the level of the virus after infection. This review focused on links between p53 in cancer immunology as well as virology to identify their commonalities that will enable future studies to be applied to immunotherapy. Since p53 was born in a cancer-related field, researchers still insufficiently studied p53 in virology. It is still not clear enough about what specific role p53 plays in virology.

Citation Download Citation

Jiaxin Liu "The role of P53 in cancer and infectious disease", Proc. SPIE 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022), 126113F (24 March 2023); https://doi.org/10.1117/12.2669658

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