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18 July 2023 Label-free analysis of single microparticles and nanoscale exosomes with two-dimensional light scattering technology
Zhuo Wang, Aishi Wang, Qiao Liu, Shuanglian Wang, Xuantao Su
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Proceedings Volume 12745, Sixteenth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2023); 1274507 (2023) https://doi.org/10.1117/12.2682909
Event: Sixteenth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2023), 2023, Haikou, China
Abstract
Liver cancer is one of the most common digestive system malignancies with an average five-year survival rate of less than 20%, while traditional methods are often unautomated, labeling required, and limited for early liver cancer detection. Exosomes are a type of extracellular vesicles with a diameter of 40-150 nm, which play important role in disease diagnosis and treatment. It is of interest to develop a label-free optical system for the analysis of nanoscale exosomes. Here, we developed a label-free two-dimensional (2D) light scattering acquisition system for the measurements of microparticles and the exosomes derived from the normal liver cells. By adjusting the thickness of the light sheet for illumination in our system, nanoparticles down to 41 nm are detected. The visualization and accurate particle size analysis of liver cell exosomes are then performed by our 2D light scattering technology. Our method is expected to have important applications in the quantitative analysis field of cellular and extracellular structures that may find potential applications in clinics such as for early cancer diagnosis.
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Zhuo Wang, Aishi Wang, Qiao Liu, Shuanglian Wang, and Xuantao Su "Label-free analysis of single microparticles and nanoscale exosomes with two-dimensional light scattering technology", Proc. SPIE 12745, Sixteenth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2023), 1274507 (18 July 2023); https://doi.org/10.1117/12.2682909
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KEYWORDS
Light scattering
Nanoparticles
Visualization
Cancer detection
Flow cytometry
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