Study on the effect of sleep modulation by transcutaneous electrical nerve stimulation based on low-high frequency coupling

Yixuan Xu; Lu Zhou; Zhiyu Qian

doi:10.1117/12.2683876

18 July 2023 Study on the effect of sleep modulation by transcutaneous electrical nerve stimulation based on low-high frequency coupling

Yixuan Xu, Lu Zhou, Zhiyu Qian

Author Affiliations +

Proceedings Volume 12745, Sixteenth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2023); 127450U (2023) https://doi.org/10.1117/12.2683876
Event: Sixteenth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2023), 2023, Haikou, China

Abstract

Sleep problems have become a social problem worldwide. Currently, drug therapies commonly used to treat sleep problems are usually accompanied by addiction and other side effects. Therefore, non-invasive brain stimulation techniques have received a lot of attention due to their non-invasive, target-adjustable and non-addictive advantages. Among these techniques, Transcutaneous Electrical Nerve Stimulation (TENS) has been proved to be effective in neuromodulation and can be used to relieve various types of pain and improve sleep quality. However, the sleep modulation mechanism and evaluation index of TENS are still unclear. In this study, four TENS modes were proposed to stimulate the nerves of the neck by superimposing high and low frequency signals to investigate their effects on assisting sleep. The electroencephalogram (EEG) signals of the subjects were collected before and after stimulation, processed and analyzed. The effect of TENS was evaluated by combined time-frequency domain analysis and Gravity Frequency (GF). The results showed that there was a significant difference in the gravity frequency before and after stimulation (p-values ⪅0.05). The highest increase in delta power was observed after each mode of stimulation. Delta power enhancement was concentrated in the frontal and occipital lobes. Therefore, all four modes may have some facilitation effect on sleep, and the two modes (mode I and mode IV) had the most significant sleep-assisting effect. Meanwhile, this study provides a new idea to determine the TENS stimulation modes and targets and to quantitatively evaluate the TENS effect.

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Yixuan Xu, Lu Zhou, and Zhiyu Qian "Study on the effect of sleep modulation by transcutaneous electrical nerve stimulation based on low-high frequency coupling", Proc. SPIE 12745, Sixteenth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2023), 127450U (18 July 2023); https://doi.org/10.1117/12.2683876

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KEYWORDS

Brain

Electroencephalography

Time-frequency analysis

Modulation

Nerve

Nerve stimulation

Frequency response

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