Research on low-cost and fast frequency-shift super-resolution microscopic imaging

Qianwei Zhang; Feihong Lin; Xiaoyu Yang; Mingwei Tang; Qing Yang; Xu Liu

doi:10.1117/12.2687083

29 November 2023 Research on low-cost and fast frequency-shift super-resolution microscopic imaging

Qianwei Zhang, Feihong Lin, Xiaoyu Yang, Mingwei Tang, Qing Yang, Xu Liu

Author Affiliations +

Proceedings Volume 12766, Advanced Optical Imaging Technologies VI; 127660X (2023) https://doi.org/10.1117/12.2687083
Event: SPIE/COS Photonics Asia, 2023, Beijing, China

Conference Poster

Abstract

Frequency-shift super-resolution (SR) microscopy, such as structured illumination microscopy (SIM) and Fourier ptychographic microscopy (FPM), can break the diffraction limit for the imaging of both fluorescently labeled and label-free samples by transferring the high spatial-frequency information into the passband of microscope. However, conventional SIM microscopy systems tend to be bulky and expensive, which limits its applications in various fields. Therefore, we’ve developed some chip-based frequency-shift SR technologies, which is compatible with conventional microscope, and can be further designed for portable imaging systems such as smart phone and so on. We also developed a deep-learning based imaging method to improve the imaging speed of frequency-shift super-resolution microscopy, which enables low-cost and fast super-resolution imaging for real-time live cell biological studies.

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Qianwei Zhang, Feihong Lin, Xiaoyu Yang, Mingwei Tang, Qing Yang, and Xu Liu "Research on low-cost and fast frequency-shift super-resolution microscopic imaging", Proc. SPIE 12766, Advanced Optical Imaging Technologies VI, 127660X (29 November 2023); https://doi.org/10.1117/12.2687083

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