Functional brain activation with dual-slope diffuse optical imaging

Jodee Frias; Giles Blaney; Fatemeh Tavakoli; Cristianne Fernandez; Angelo Sassaroli; Sergio Fantini

doi:10.1117/12.3001890

12 March 2024 Functional brain activation with dual-slope diffuse optical imaging

Jodee Frias, Giles Blaney, Fatemeh Tavakoli, Cristianne Fernandez, Angelo Sassaroli, Sergio Fantini

Proceedings Volume 12828, Neural Imaging and Sensing 2024; 1282803 (2024) https://doi.org/10.1117/12.3001890
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

While near-infrared spectroscopy has been shown to be a useful technique for the non-invasive monitoring of cerebral hemodynamics, sensitivity to superficial hemodynamic changes continues to be a challenge in the field. Here, we apply a previously designed hexagonal dual-slope module to human subjects during a visual stimulation protocol. The enrolled subjects have different scalp-to-cortex distances, as measured with ultrasound imaging. This work investigates the cerebral hemodynamic response to visual stimulation as measured non-invasively by optical intensity (I) collected with a single distance (SD) or dual-slope (DS) source-detector arrangement [SDI(25 mm), SDI(35 mm), DSI]. The observed results in relation to scalp-to-cortex distance are then validated through theoretical simulations in two-layered media, and these simulations confirm that as the cortical depth increases the sensitivity to the brain decreases faster for single-distance measurements than dual-slope measurements. This finding supports the value of dual-slope measurements for enhanced sensitivity to the brain.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Jodee Frias, Giles Blaney, Fatemeh Tavakoli, Cristianne Fernandez, Angelo Sassaroli, and Sergio Fantini "Functional brain activation with dual-slope diffuse optical imaging", Proc. SPIE 12828, Neural Imaging and Sensing 2024, 1282803 (12 March 2024); https://doi.org/10.1117/12.3001890

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