Novel biomarker for cardiovascular disease by assessing retinal blood vessels with polarization sensitive optical coherence tomography

H. Afsharan; G. Dwivedi; D. Silva; B. Cense

doi:10.1117/12.3003617

12 March 2024 Novel biomarker for cardiovascular disease by assessing retinal blood vessels with polarization sensitive optical coherence tomography

H. Afsharan, G. Dwivedi, D. Silva, B. Cense

Author Affiliations +

Proceedings Volume 12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII; 1283002 (2024) https://doi.org/10.1117/12.3003617
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Preliminary data obtained with PS-OCT through the eyes of hypertensives suggests a mechanistic connection between arterial health and hypertension. In this study we want to determine whether arterial health may be more predictive of negative clinical outcomes than hypertension and blood glucose. Patients with various stages of hypertension, diabetes and coronary artery disease were recruited from Fiona Stanley Hospital (Perth). They were subsequently imaged with PS-OCT. The data were analyzed for retinal vessel wall thickness and vessel wall birefringence. We demonstrated that the combination of blood vessel wall tissue structure and wall thickness, a recognized clinical biomarker (Afsharan et al, BOE, 2021), could diagnose hypertension and diabetes with high sensitivity and specificity. PS-OCT measurements can detect the smallest changes related to cardiovascular disease in the retina before the disease manifests itself clinically. The method is cheap, noninvasive and easy to apply, which makes it highly suitable for screening, especially in underserved communities.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

H. Afsharan, G. Dwivedi, D. Silva, and B. Cense "Novel biomarker for cardiovascular disease by assessing retinal blood vessels with polarization sensitive optical coherence tomography", Proc. SPIE 12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII, 1283002 (12 March 2024); https://doi.org/10.1117/12.3003617

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