Gold nanoparticles for safe delivery of cisplatin

Yoray Sharon; Menachem Motiei; Chen Tzror-Azankot; Tamar Sadan; Rachela Popovtzer; Eli Rosenbaum

doi:10.1117/12.3005425

13 March 2024 Gold nanoparticles for safe delivery of cisplatin

Yoray Sharon, Menachem Motiei, Chen Tzror-Azankot, Tamar Sadan, Rachela Popovtzer, Eli Rosenbaum

Proceedings Volume 12858, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XXI; 128580D (2024) https://doi.org/10.1117/12.3005425
Event: SPIE BiOS, 2024, San Francisco, California, United States

Conference Poster

Abstract

Cisplatin (CP) is the primary standard treatment for bladder cancer. Nevertheless, CP has side effects, particularly nephrotoxicity. This limits the treatment of a notable portion of advanced bladder cancer patients with cisplatin. We have developed gold nanoparticles that conjugate CP (CP-AuNPs) for safer delivery to tumors. Here, we investigated the biodistribution of the CP-AuNP conjugates in a mouse model of bladder cancer, to characterize the distinct role of CPAuNP in delivering and releasing CP in tumor and tissues. Effect of the CP-AuNPs on weight and kidney was also investigated. This study can provide insights into the potential safety of CP-AuNP for bladder cancer treatment.

Citation Download Citation

Yoray Sharon, Menachem Motiei, Chen Tzror-Azankot, Tamar Sadan, Rachela Popovtzer, and Eli Rosenbaum "Gold nanoparticles for safe delivery of cisplatin", Proc. SPIE 12858, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XXI, 128580D (13 March 2024); https://doi.org/10.1117/12.3005425

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