X-ray diffraction imaging of glioblastoma and ductal carcinoma in-situ

Joel A. Greenberg; Turner Richmond; Zachary W. Gude; Xiang Li; Arnav Nanda; David Coccarelli; Rachel Factor; Shannon McCall; Anuj Kapadia

doi:10.1117/12.3006600

1 April 2024 X-ray diffraction imaging of glioblastoma and ductal carcinoma in-situ

Joel A. Greenberg, Turner Richmond, Zachary W. Gude, Xiang Li, Arnav Nanda, David Coccarelli, Rachel Factor, Shannon McCall, Anuj Kapadia

Author Affiliations +

Proceedings Volume 12925, Medical Imaging 2024: Physics of Medical Imaging; 129250I (2024) https://doi.org/10.1117/12.3006600
Event: SPIE Medical Imaging, 2024, San Diego, California, United States

Abstract

Specimen radiography is critical to cancer diagnostics, but conventional transmission X-ray imaging often lacks the contrast to conclusively differentiate healthy from cancerous tissue. X-ray diffraction (XRD), however, has been shown to be sensitive to structural changes in tissue that are correlated with cancer progression. We use a home-built XRD imaging system to study glioblastoma in brain tissue and ductal carcinoma in situ (DCIS) in breast tissue, and identify both commonalities and unique aspects of cancer structural changes in the brain and breast. These findings demonstrate the potential for XRD imaging as a new tool for use in both research and diagnostic medicine.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Joel A. Greenberg, Turner Richmond, Zachary W. Gude, Xiang Li, Arnav Nanda, David Coccarelli, Rachel Factor, Shannon McCall, and Anuj Kapadia "X-ray diffraction imaging of glioblastoma and ductal carcinoma in-situ", Proc. SPIE 12925, Medical Imaging 2024: Physics of Medical Imaging, 129250I (1 April 2024); https://doi.org/10.1117/12.3006600

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