spectral fluorescence analysis and photodynamic activity of some phthalocyanines in experiments in vivo

V. E. Normansky M.D.; Natalia N. Zharkova; M. V. Baryshev; E. A. Lukinetc; O. L. Kaliya; Victor B. Loschenov

doi:10.1117/12.23766

1 September 1990 Spectral fluorescence analysis and photodynamic activity of some phthalocyanines in experiments in vivo

V. E. Normansky M.D., Natalia N. Zharkova, M. V. Baryshev, E. A. Lukinetc, O. L. Kaliya, Victor B. Loschenov

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Proceedings Volume 1353, First International Conference on Lasers and Medicine; (1990) https://doi.org/10.1117/12.23766
Event: First International Conference on Lasers and Medicine, 1990, Tashkent, Uzbekistan

Abstract

A great variety of new chemical compounds, potential photosensitizers, require testing their photodynamic activity ( PDA ) and tumor localizing capacity. Comparative analysis of phthalocyanines according to qiven criteria seems to be urgent, phthalocyanines being most prospective photosensitizers for photodynamic therapy ( PDT ) of malignant tumors ( 1, 2 ). The absence of scientificly based correlations between the compound chemical structure and its photodynamic activity puts forward the task of initial screening estimation of photosensitizing and tumor localizing properties of chemical compounds.

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V. E. Normansky M.D., Natalia N. Zharkova, M. V. Baryshev, E. A. Lukinetc, O. L. Kaliya, and Victor B. Loschenov "Spectral fluorescence analysis and photodynamic activity of some phthalocyanines in experiments in vivo", Proc. SPIE 1353, First International Conference on Lasers and Medicine, (1 September 1990); https://doi.org/10.1117/12.23766

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