Improved frequency-filtering-based system for prescreening of cytological samples

Dariusz Litwin

doi:10.1117/12.155706

3 September 1993 Improved frequency-filtering-based system for prescreening of cytological samples

Dariusz Litwin

Proceedings Volume 1889, Holography, Interferometry, and Optical Pattern Recognition in Biomedicine III; (1993) https://doi.org/10.1117/12.155706
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

Mass examinations of women should be carried out for early detection of cervical cancer. An automated system for selection of suspicious smears from a large number of negative cases has to be applied. Band-pass spatial frequency filtering technique may be used for the fast reduction of information in the image by converting dark stained nuclei into bright spots. Their intensities depend on the nuclei diameters. The enlarged nucleus is a symptom of the disease. However the filtering system suffers from false alarms produced by amplitude and phase artifacts. In this paper two alternative solutions have been presented. Both employ unequal spectral transmittance of the stain used for sample preparation which is high for infrared and low for the visible spectrum. The first solution consists in the nuclei contrast comparison in visible and infrared light in the direct images. In the second solution helium- neon and infrared diode lasers are used to perform the filtering process and the modified images are compared. The system has been successfully tested on the routine samples.

Citation Download Citation

Dariusz Litwin "Improved frequency-filtering-based system for prescreening of cytological samples", Proc. SPIE 1889, Holography, Interferometry, and Optical Pattern Recognition in Biomedicine III, (3 September 1993); https://doi.org/10.1117/12.155706

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