Factors affecting the outcome of excimer laser photorefractive keratectomy: a preliminary multivariable regression analysis

Ezra I. Maguen M.D.; Thanassis Papaioannou; Anthony B. Nesburn M.D.; James J. Salz M.D.; Cathy Warren; Warren S. Grundfest M.D.

doi:10.1117/12.240063

17 May 1996 Factors affecting the outcome of excimer laser photorefractive keratectomy: a preliminary multivariable regression analysis

Ezra I. Maguen M.D., Thanassis Papaioannou, Anthony B. Nesburn M.D., James J. Salz M.D., Cathy Warren, Warren S. Grundfest M.D.

Author Affiliations +

Proceedings Volume 2673, Ophthalmic Technologies VI; (1996) https://doi.org/10.1117/12.240063
Event: Photonics West '96, 1996, San Jose, CA, United States

Abstract

Multivariable regression analysis was used to evaluate the combined effects of some preoperative and operative variables on the change of refraction following excimer laser photorefractive keratectomy for myopia (PRK). This analysis was performed on 152 eyes (at 6 months postoperatively) and 156 eyes (at 12 months postoperatively). The following variables were considered: intended refractive correction, patient age, treatment zone, central corneal thickness, average corneal curvature, and intraocular pressure. At 6 months after surgery, the cumulative R₂ was 0.43 with 0.38 attributed to the intended correction and 0.06 attributed to the preoperative corneal curvature. At 12 months, the cumulative R² was 0.37 where 0.33 was attributed to the intended correction, 0.02 to the preoperative corneal curvature, and 0.01 to both preoperative corneal thickness and to the patient age. Further model augmentation is necessary to account for the remaining variability and the behavior of the residuals.

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Ezra I. Maguen M.D., Thanassis Papaioannou, Anthony B. Nesburn M.D., James J. Salz M.D., Cathy Warren, and Warren S. Grundfest M.D. "Factors affecting the outcome of excimer laser photorefractive keratectomy: a preliminary multivariable regression analysis", Proc. SPIE 2673, Ophthalmic Technologies VI, (17 May 1996); https://doi.org/10.1117/12.240063

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KEYWORDS

Excimer lasers

Eye models

Statistical analysis

Analytical research

Laser applications

Medical research

Refraction

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