Enhancement of photosensitization efficiency by various combinations with radiosensitization in an experimental Ehrlich ascites tumor

Zivile Luksiene; G. Kaspariunaite; E. Aleknavicius; Konstantinas Povilas Valuckas

doi:10.1117/12.260776

4 December 1996 Enhancement of photosensitization efficiency by various combinations with radiosensitization in an experimental Ehrlich ascites tumor

Zivile Luksiene, G. Kaspariunaite, E. Aleknavicius, Konstantinas Povilas Valuckas

Author Affiliations +

Proceedings Volume 2924, Photochemotherapy: Photodynamic Therapy and Other Modalities II; (1996) https://doi.org/10.1117/12.260776
Event: BiOS Europe '96, 1996, Vienna, Austria

Abstract

According to our previous results porphyrin can interact not only with visible light but with ionizing radiation also. This phenomenon gives us new possibility to combine photosensitization with radiosensitization. Data obtained on BALB/c mice with 7-day Ehrlich ascites tumors pretreated with 30 mg/kg HP dimethylether (not toxic and not mutagenic concentration) and irradiated with ⁶⁰Co source (2 Gy) and visible light source (5 J/cm²) showed remarkable inhibition of tumor growth. Two Gy alone inhibited Ehrlich ascites tumor growth by 17%, whereas combination of 30 mg/kg HPde and 2 Gy (radiosensitization) -- by 38%. Photosensitization (30 mg/kg HPde plus 5 J/cm²) showed 37% tumor growth inhibition. Combination of photosensitization with radiosensitization inhibited tumor growth by 87%. It is important to note, that sequence of treatments (radiosensitization - 1 h - photosensitization or photosensitization - 1 h - radiosensitization) had no influence on tumor growth inhibition.

Citation Download Citation

Zivile Luksiene, G. Kaspariunaite, E. Aleknavicius, and Konstantinas Povilas Valuckas "Enhancement of photosensitization efficiency by various combinations with radiosensitization in an experimental Ehrlich ascites tumor", Proc. SPIE 2924, Photochemotherapy: Photodynamic Therapy and Other Modalities II, (4 December 1996); https://doi.org/10.1117/12.260776

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